to screen for proteins with phosphorylated tyrosines
The recognition of phosphorylated tyrosine residues by SH2 domains on interacting proteins is an important signaling mechanism in metazoans. This collection contains 130 human SH2 domains cloned into the bacterial expression vector pET28. Possible applications include screening for previously unidentified proteins with phosphorylated tyrosines or identifying the known signaling pathways employed in a novel biological process.
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| We provide certain clone resources developed by leading academic laboratories. Many of these resources address the needs of specialized research communities not served by other commercial entities. In order to provide these as a public resource, we depend on the contributing academic laboratories for quality control. Therefore, these are distributed in the format provided by the contributing institution "as is" with no additional product validation or guarantee. Thermo Fisher Scientific is not responsible for any errors or performance issues. Additional information can be found in the product manual as well as in associated published articles (if available). Alternatively, the source academic institution can be contacted directly for troubleshooting. |
This collection is shipped on dry ice as E. coli cultures in 96-well microplates and should be stored at –80°C.
Liu BA et al (2006). The human and mouse complement of SH2 domain proteins—establishing the boundaries of phosphotyrosine signaling. Molecular Cell22, 851–868
