Reduce mRNA levels of essential yeast genes by four- to ten-fold with the Decreased Abundance by mRNA Perturbation (DAmP) Yeast Library. Dr. Jonathan Weissman’s lab at the University of California, San Francisco has created a library of essential gene hypomorphic alleles whereby the 3’ untranslated region (UTR) of each essential gene present in the collection was disrupted with an antibiotic resistance cassette. The library is available in either haploid or heterozygous diploid formats.
Possible applications:
- Explore interactions of essential genes
- Sensitive detection of growth rate changes
- High resolution functional analysis of the yeast genome
*Please note that the creators of this resource list the number of genes they believe to be essential in each collection in the product description. DAmP strains were created for additional genes and included in the collections. Therefore the number of strains included in each collection is greater than the number listed in the product description.|
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