Shinya Yamanaka’s group (Kyoto University)¹ and James Thompson’s group (University of Wisconsin)² have each discovered a set of 4 human genes that, when overexpressed in human fibroblasts, induce the formation of cells that closely resemble human embryonic stem cells.
These two overlapping sets together contain 6 unique genes for which Open Biosystems has a complete set of analytical tools, including full-length cDNAs for overexpression, short hairpin RNAs (shRNAs) for knockdown, and high-quality antibodies for the detection of the gene products. Click on the links below for more information about each reagent. These may be purchased individually or the entire set is available as the Human Pluripotency Tool Kit (Cat No PPK4918) for a savings of 20%. The complete list of components may be downloaded by clicking on the icon in Purchasing Information.
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*Full-length cDNAs matching each reference sequence were found by protein and nucleotide BLAST and differ from the reference sequence by no more than one amino acid residue within the coding region. Mismatches, including alternative splicing, were permitted in the untranslated regions.
