|
Genes
| Band |
| BCL10 | 1p22.3 |
BCL9
| 1q21.1 |
MUC1
| 1q21 |
BCL11A
| 2p16.1 |
IgK@
| 2p11/2p12 |
BCL6
| 3q27.3 |
FGFR3
| 4p16. |
IL3
| 5q23.3 |
CCND3
| 6p21.10 |
TCRG
| 7p14.1 |
CDK6
| 7q21.2 |
MYC
| 8q24.21 |
PAX5
| 9p13.2 |
| NFKB2 | 10q24.32 |
| RCK/DDX6 | 11q23.3 |
| CCND1 (BCL1) | 11q13.3 |
| BCL7A | 12q24.31 |
| TCRD | 14q11.2 |
| TCRA | 14q11.2 |
| IGH | 14q32.33 |
| C-MAF | 16q23.2 |
| BCL2 | 18q21.33 |
| BCL3 | 19q13.32 |
| IgL@ | 22q11.1 - 22q11.2 |
|
contains CCAP BACs that span the known breakpoint regions
Many sub-types of B-cell leukemias are associated with chromosomal translocations involving the Immunoglobulin heavy chain gene (IgH@) on chromosome 14q32. Because of the somatic rearrangement of the IgH gene that occurs normally, this area can accidentally associate with a proto-oncogene in a chromosomal translocation, thus activating it, and resulting in a B-cell neoplasia. Similarly, the translocation of Immunoglobulin light chain Kappa and Lambda genes can also result in B-cell neoplasms. Below is a table of genes involved in these translocations. This disease specific set contains CCAP BACs that span the known breakpoint regions in order to detect disruption of the normal sequence using FISH.
Shipping Information:
Clones are provided as a live culture in a 2ml tube. Each
tube contains LB medium supplemented with 8% glycerol and the
appropriate antibiotic. we will ship your order at room temperature via
express delivery. Store the clones at -80°C.
